Amelioration of Lipids by Eugenia Caryophyllus Extract in Atherogenic Diet Induced Hyperlipidemia

The present study focus on the lipid lowering potential of aqueous ethanolic extract of Eugenia caryophyllus in high fat diet induced hyperlipidemia. Hyperlipidemia was induced in rats by oral administration of high fat diet for six weeks. The extract was thereafter administered at two different doses of 200mg/kg and 400mg/kg body weight for next six weeks to hyperlipidemic rats. Atorvastatin was used as a reference standard. The extract exhibited anti-hyperlipidemic activity in dose dependent manner. The dose of 400mg/kg exhibited maximum antihyperlipidemic efficacy with values of total cholesterol as 145.84±1.11mg/dl, LDL-C as 87.85±1.75mg/dl, VLDL-C as 28.52±0.30mg/dl, HDL-C as 29.47±1.28mg/dl, atherogenic index as 4.99±0.21 which was comparable to the standard drug Atorvastatin with values of total cholesterol as 163.79±2.21mg/dl, LDL-C as 105.98±2.32mg/dl, VLDL-C as 28.78±0.35mg/dl, HDL-C as 29.03±1.18mg/dl, atherogenic index as 5.68±0.22 respectively. These findings support the use of the extract as an adjuvant with existing therapy for treatment of hyperlipidemia.